Windows Server 2012 R2 or Windows Server 2016 (64-bit)
Database (Optional): MySQL/SQLite/PostgreSQL + DB Connector for Python
Knowledge of Php, Apache, and Webserver technologies would come in handy.
A quick note on wfastcgi and WSGI:
There aren’t really any issues in targetting Windows Server and IIS as the production environment for your Django application, other than including the wfastcgi Python package (https://pypi.python.org/pypi/wfastcgi) in your application.
wfastcgi is maintained by Microsoft and provides a file that serves as the entry point of the IIS handler for WSGI applications in Python. It’s similar in purpose to a tool like Gunicorn (http://gunicorn.org), with the end result being that requests that come into IIS are handed off to the Python application for processing.